Skp2 is a crucial component of SCFSkp2 E3 ubiquitin ligase and is often overexpressed in
various types of cancer, including prostate cancer (PCa). The epithelial-to-mesenchymal …

Prostatic neuroendocrine cells (NE) are an integral part of prostate cancer (PCa) and are
associated with PCa progression. As the current androgen deprivation therapy with anti …

Prostate cancer (PCa) represents the fifth cause of cancer death in men. Currently,
chemotherapeutic agents for the treatment of cancers, including PCa, mainly inhibit tumor …

Background Prostate cancers frequently metastasize to bone, where the best
microenvironment for distant colonization is provided. Since osteotropic metastasis of …

Administration of the microtubule inhibitor docetaxel is a common treatment for metastatic
castration-resistant prostate cancer (mCRPC) and results in prolonged patient overall …

Patients with metastatic castration-resistant prostate cancer (mCRPC) develop resistance to
conventional therapies including docetaxel (DTX). Identifying molecular pathways …

Osteopontin (OPN) is a phosphoprotein that activates several aspects of tumor progression.
Alternative splicing of the OPN primary transcript generates three splicing isoforms, OPNa …

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men in
Western countries, and there is still an urgent need for a better understanding of PCa …

Docetaxel efficiency in the therapy of prostate cancer (PCa) patients is limited due to the
development of chemoresistance. Recent studies have implied a role of INPP4B in tumor …

Objective Accumulating evidence has demonstrated the protumor role of estrogen receptor
(ER)–mediated signaling in multiple cancer types, which is distinct from this signaling in sex …