Hydrogen/deuterium exchange mass spectrometry (HDX-MS) has within the last 25 years
evolved to become a well-established technique for analysing the solution-phase …

The conformational dynamism of proteins is well established. Rather than having a single
structure, proteins are more accurately described as a conformational ensemble that exists …

NF-κB functions as modulator of T cell receptor-mediated signaling and transcriptional
regulator of miR-34a. Our in silico analysis revealed that miR-34a impacts the NF-κB …

Data produced by hydrogen-exchange monitoring experiments have been used in structural
studies of molecules for several decades. Despite uncertainties about the structural …

MiRNAs play a central role in physiological and pathological processes. Both for the
biological understanding and for their clinical application, it is essential to understand the …

Antigen presentation by major histocompatibility complex (MHC) proteins to T-cell receptors
(TCRs) plays a crucial role in triggering the adaptive immune response. Most of our …

Binding of the T cell receptor (TCR) to its cognate, peptide antigen-loaded major
histocompatibility complex (pMHC) is a key interaction for triggering T cell activation and …

The structure and conformation adopted by protein vaccine antigens significantly influence
the exposure of their antigenic determinants. Structural knowledge of antigens in native state …