Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic
lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that …

Osteoclasts are tissue-specific polykaryon bone-resorbing cells derived from the monocyte/
macrophage hematopoietic lineage with specialized functions required for the adhesion of …

Bone-resorbing osteoclasts are vital for postnatal bone health, as increased differentiation or
activity results in skeletal pathologies such as osteoporosis. The metabolism of mature …

The osteoclast is a giant cell that resorbs calcified matrix by secreting acids and
collagenolytic enzymes. The molecular mechanisms underlying metabolic adaptation to the …

Osteoclasts are the cells responsible for bone resorption, a process that is essential for the
maintenance of healthy bones. Bone diseases, such as osteoporosis, which are …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating progressive disease with
limited therapeutic options. Airway macrophages (AMs) are key components of the defense …

Flavonoids are micronutrients widely present in food of plant origin. They have been
attributed pharmacological properties such as anticancer and prevention of age‐related …

HTT mediates antidepressant‐sensitive clearance of 5‐HT after its release into neural
synapses. We found increased expression of 5‐HTT in RANKL‐induced osteoclast‐like …

A variety of osteolytic factors have been identified from breast cancer cells leading to
osteolysis, but less is known about which factor plays an essential role in the initiation …

Osteoporosis is a metabolic bone disorder associated with compromised bone strength and
an increased risk of fracture. Inhibition of the differentiation of bone-resorbing osteoclasts is …