Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Inflammasomes are large cytosolic multiprotein complexes assembled in response to
infection and cellular stress, and are crucial for the activation of inflammatory caspases and …

Monitoring of the cytosolic compartment by the innate immune system for pathogen-encoded
products or pathogen activities often enables the activation of a subset of caspases. In most …

Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …

Cellular Phenotype and Apoptosis: The function of epithelial tissues is the protection of the
organism from chemical, microbial, and physical challenges which is indispensable for …

Canonical activation of the inflammasome is critical to promote caspase-1-dependent
maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic …

The murine caspase-11 non-canonical inflammasome responds to various bacterial
infections. Caspase-11 activation-induced pyroptosis, in response to cytoplasmic …

Inflammatory caspases play a central role in innate immunity by responding to cytosolic
signals and initiating a twofold response. First, caspase‐1 induces the activation and …

Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

Inflammatory and apoptotic caspases are central players in inflammation and apoptosis,
respectively. However, recent studies have revealed that these caspases have functions …