Metabolomics and type 2 diabetes risk: an updated systematic review and meta-analysis of prospective cohort studies
BACKGROUND Due to the rapidly increasing availability of metabolomics data in
prospective studies, an update of the meta evidence on metabolomics and type 2 diabetes …
prospective studies, an update of the meta evidence on metabolomics and type 2 diabetes …
[HTML][HTML] Metabolomics in diabetes and diabetic complications: insights from epidemiological studies
Q Jin, RCW Ma - Cells, 2021 - mdpi.com
The increasing prevalence of diabetes and its complications, such as cardiovascular and
kidney disease, remains a huge burden globally. Identification of biomarkers for the …
kidney disease, remains a huge burden globally. Identification of biomarkers for the …
Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease
Complex diseases, such as coronary artery disease (CAD), are often multifactorial, caused
by multiple underlying pathological mechanisms. Here, to study the multifactorial nature of …
by multiple underlying pathological mechanisms. Here, to study the multifactorial nature of …
Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort …
Objective Tryptophan can be catabolised to various metabolites through host kynurenine
and microbial indole pathways. We aimed to examine relationships of host and microbial …
and microbial indole pathways. We aimed to examine relationships of host and microbial …
[HTML][HTML] Kynurenine pathway in diabetes mellitus—novel pharmacological target?
K Kozieł, EM Urbanska - Cells, 2023 - mdpi.com
The tryptophan–kynurenine pathway (Trp–KYN) is the major route for tryptophan conversion
in the brain and in the periphery. Kynurenines display a wide range of biological actions …
in the brain and in the periphery. Kynurenines display a wide range of biological actions …
[HTML][HTML] Comparison of fecal and blood metabolome reveals inconsistent associations of the gut microbiota with cardiometabolic diseases
Blood metabolome is commonly used in human studies to explore the associations of gut
microbiota-derived metabolites with cardiometabolic diseases. Here, in a cohort of 1007 …
microbiota-derived metabolites with cardiometabolic diseases. Here, in a cohort of 1007 …
[HTML][HTML] Prediction of type 2 diabetes using genome-wide polygenic risk score and metabolic profiles: a machine learning analysis of population-based 10-year …
Background Previous work on predicting type 2 diabetes by integrating clinical and genetic
factors has mostly focused on the Western population. In this study, we use genome-wide …
factors has mostly focused on the Western population. In this study, we use genome-wide …
[HTML][HTML] Gut microbiota-derived metabolites as key actors in type 2 diabetes mellitus
L Du, Q Li, H Yi, T Kuang, Y Tang, G Fan - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Type 2 diabetes mellitus (T2DM) is one of the most risk factors threatening human health.
Although genetic and environmental factors contribute to the development of T2DM, gut …
Although genetic and environmental factors contribute to the development of T2DM, gut …
[图书][B] Advanced nutrition: macronutrients, micronutrients, and metabolism
CD Berdanier, LA Berdanier, J Zempleni - 2008 - taylorfrancis.com
Nutrition science has evolved considerably in the past decade with new concepts and
discoveries. In response, advanced nutrition courses now encompass material on …
discoveries. In response, advanced nutrition courses now encompass material on …
[HTML][HTML] Amino acids, microbiota-related metabolites, and the risk of incident diabetes among normoglycemic Chinese adults: Findings from the 4C study
Although previous studies suggest that amino acids (AAs) and microbiota-related
metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain …
metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain …