The manifold roles of sphingolipids in viral infections

E Avota, J Bodem, J Chithelen, P Mandasari… - Frontiers in …, 2021 - frontiersin.org
Sphingolipids are essential components of eukaryotic cells. In this review, we want to
exemplarily illustrate what is known about the interactions of sphingolipids with various …

The role of lipid metabolism in influenza A virus infection

Y Zhou, J Pu, Y Wu - Pathogens, 2021 - mdpi.com
Influenza A virus (IAV) is an important zoonotic pathogen that can cause disease in animals
such as poultry and pigs, and it can cause infection and even death in humans, posing a …

Glucosylceramide synthase inhibitors prevent replication of SARS-CoV-2 and influenza virus

EB Vitner, H Achdout, R Avraham, B Politi… - Journal of Biological …, 2021 - ASBMB
The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a major threat to global health. Vaccines are ideal solutions …

Recent Progress in the Development of Opaganib for the Treatment of Covid-19

CD Smith, LW Maines, SN Keller… - Drug Design …, 2023 - Taylor & Francis
The Covid-19 pandemic driven by the SARS-CoV-2 virus continues to exert extensive
humanitarian and economic stress across the world. Although antivirals active against mild …

Extracellular vesicle depletion and UGCG overexpression mitigate the cell density effect in HEK293 cell culture transfection

P Pérez-Rubio, J Lavado-García, L Bosch-Molist… - … Therapy Methods & …, 2024 - cell.com
The hitherto unexplained reduction of cell-specific productivity in transient gene expression
(TGE) at high cell density (HCD) is known as the cell density effect (CDE). It currently …

The implication of sphingolipids in viral infections

S Thomas, SV Samuel, A Hoch, C Syphurs… - International Journal of …, 2023 - mdpi.com
Sphingolipids are involved in cell signaling and metabolic pathways, and their metabolites
play a critical role in host defense against intracellular pathogens. Here, we review the …

Sphingolipids: effectors and Achilles heals in viral infections?

S Schneider-Schaulies, F Schumacher, D Wigger… - Cells, 2021 - mdpi.com
As viruses are obligatory intracellular parasites, any step during their life cycle strictly
depends on successful interaction with their particular host cells. In particular, their …

Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking

L Andersson, M Cinato, I Mardani… - European heart …, 2021 - academic.oup.com
Aims Cardiac injury and remodelling are associated with the rearrangement of cardiac
lipids. Glycosphingolipids are membrane lipids that are important for cellular structure and …

Glucosylceramide in bunyavirus particles is essential for virus binding to host cells

ZM Uckeley, M Duboeuf, Y Gu, A Erny… - Cellular and Molecular …, 2024 - Springer
Hexosylceramides (HexCer) are implicated in the infection process of various pathogens.
However, the molecular and cellular functions of HexCer in infectious cycles are poorly …

[HTML][HTML] Identification of potent small molecule inhibitors of SARS-CoV-2 entry

S Mediouni, H Mou, Y Otsuka, JA Jablonski, RS Adcock… - Slas Discovery, 2022 - Elsevier
The severe acute respiratory syndrome coronavirus 2 responsible for COVID-19 remains a
persistent threat to mankind, especially for the immunocompromised and elderly for which …