Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)

JI Aguirre, EJ Castillo, DB Kimmel - Bone, 2021 - Elsevier
Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe adverse event
affecting patients with cancer and patients with osteoporosis who have been treated with …

From osteoclast differentiation to osteonecrosis of the jaw: molecular and clinical insights

A Anesi, L Generali, L Sandoni, S Pozzi… - International journal of …, 2019 - mdpi.com
Bone physiology relies on the delicate balance between resorption and formation of its
tissue. Bone resorption depends on a process called osteoclastogenesis in which bone …

Medication-related osteonecrosis of jaws (MRONJ) prevention and diagnosis: Italian consensus update 2020

G Campisi, R Mauceri, F Bertoldo, G Bettini, M Biasotto… - 2020 - mdpi.com
The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its
prevention play a role of great and rising importance, not only on the Quality of Life (QoL) of …

[HTML][HTML] Bisphosphonates and osteonecrosis of the jaws: Clinical and forensic aspects

D Nogueira, IM Caldas, RJ Dinis-Oliveira - Archives of Oral Biology, 2023 - Elsevier
Objective This manuscript aims to provide a comprehensive review of the current knowledge
in the pathophysiology, diagnosis, prevention, and other relevant forensic and clinical …

Early imaging signs of the use of antiresorptive medication and MRONJ: a systematic review

C Moreno-Rabié, H Gaêta-Araujo… - Clinical oral …, 2020 - Springer
Objective The main aim is to identify, by means of different imaging modalities, the early
bone changes in patients “at risk” and in stage 0 MRONJ. Materials and methods A search of …

[HTML][HTML] Novel insights into the pharmacological modulation of human periodontal ligament stem cells by the amino-bisphosphonate Alendronate

A Di Vito, E Chiarella, J Sovereto, J Bria… - European Journal of …, 2023 - Elsevier
Alendronate (ALN) is a second-generation bisphosphonate widely used for osteoporosis
and cancer-induced bone lesions. Many studies have confirmed a strong relationship …

Relationship between trabecular bone architecture and early dental implant failure in the posterior region of the mandible

LFP Nicolielo, J Van Dessel, R Jacobs… - Clinical Oral …, 2020 - Wiley Online Library
Objective To investigate the relationship between preoperative trabecular bone structure
and implant outcome based on bone morphometric bone parameters from CBCT scans …

Influence of antiresorptive/antiangiogenic therapy on the extension of experimentally induced peri-implantitis lesions

F Schwarz, K Becker, F Lukman, KM Müller… - Clinical oral …, 2023 - Springer
Objectives To investigate the extension of experimentally induced peri-implantitis lesions
under various antiresorptive and antiangiogenic medications. Material and methods Fourty …

Zoledronic acid modulates osteoclast apoptosis through activation of the NF-κB signaling pathway in ovariectomized rats

YT Cheng, J Liao, Q Zhou, H Huo… - Experimental …, 2021 - journals.sagepub.com
Bone mass loss (osteoporosis) seen in postmenopausal women is an adverse factor for
implant denture. Using an ovariectomized rat model, we studied the mechanism of estrogen …

Antiresorptive drug-related changes of the mandibular bone densitiy in medication-related osteonecrosis of the jaw patients

N Heim, W Götz, FJ Kramer… - Dentomaxillofacial …, 2019 - academic.oup.com
Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a well known side-effect
of anti-resorptive drugs. Changes in bone density might potentially constitute the …