Somatosensory neurons mediate our sense of touch. They are critically involved in
transducing pain and itch sensations under physiological and pathological conditions, along …

The sensations of pain, itch, and cold often interact with each other. Pain inhibits itch,
whereas cold inhibits both pain and itch. TRPV1 and TRPA1 channels transduce pain and …

Spontaneous itch and pain are the most common symptoms in various skin diseases,
including allergic contact dermatitis (ACD). The chemokine (CC motif) ligand 2 (CCL2, also …

The cellular response to stress involves the recruitment and coordination of molecular
signaling pathways that prevent cell death. D-dopachrome tautomerase (DDT) is an enzyme …

Persistent itch is a common symptom of allergic contact dermatitis (ACD) and represents a
significant health burden. The chemokine CXCL10 is predominantly produced by epithelial …

Although joint pain in rheumatoid arthritis (RA) is conventionally thought to result from
inflammation, arthritis pain and joint inflammation are at least partially uncoupled. This …

TRP-channels are the most prominent family of ligand-gated ion channels for pain
perception. In sensory neurons, TRPV1–V4, TRPA1 and TRPM8 are expressed and are …

The Fc gamma receptor I (FcγRI or CD64) is the only human Fc receptor with a high affinity
for monomeric IgG. It plays a crucial role in immunity, as it mediates cellular effector …

Chronic pruritus is a prominent symptom of allergic contact dermatitis (ACD) and represents
a huge unmet health problem. However, its underlying cellular and molecular mechanisms …

Calcium release-activated calcium (CRAC) channels are unique among ion channels that
are activated in response to depletion of intracellular calcium stores and are highly …