Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

[HTML][HTML] Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles

NR Tykocki, EM Boerman… - Comprehensive Physiology, 2017 - ncbi.nlm.nih.gov
Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Physiological implications of hydrogen sulfide: a whiff exploration that blossomed

R Wang - Physiological reviews, 2012 - journals.physiology.org
The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to
plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S …

Vascular biology of hydrogen sulfide

NL Kanagy, C Szabo… - American Journal of …, 2017 - journals.physiology.org
Hydrogen sulfide (H2S) is a ubiquitous signaling molecule with important functions in many
mammalian organs and systems. Observations in the 1990s ascribed physiological actions …

Taurine supplementation lowers blood pressure and improves vascular function in prehypertension: randomized, double-blind, placebo-controlled study

Q Sun, B Wang, Y Li, F Sun, P Li, W Xia, X Zhou… - …, 2016 - Am Heart Assoc
Taurine, the most abundant, semiessential, sulfur-containing amino acid, is well known to
lower blood pressure (BP) in hypertensive animal models. However, no rigorous clinical trial …

[HTML][HTML] Hydrogen sulfide in pharmacotherapy, beyond the hydrogen sulfide-donors

E Zaorska, L Tomasova, D Koszelewski, R Ostaszewski… - Biomolecules, 2020 - mdpi.com
Hydrogen sulfide (H2S) is one of the important biological mediators involved in
physiological and pathological processes in mammals. Recently developed H2S donors …

Potassium channels in regulation of vascular smooth muscle contraction and growth

WF Jackson - Advances in Pharmacology, 2017 - Elsevier
Potassium channels importantly contribute to the regulation of vascular smooth muscle
(VSM) contraction and growth. They are the dominant ion conductance of the VSM cell …

Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension

S Gheibi, S Jeddi, K Kashfi, A Ghasemi - Biochemical pharmacology, 2018 - Elsevier
Nitric oxide (NO) and hydrogen sulfide (H 2 S) are two gasotransmitters that are produced in
the vasculature and contribute to the regulation of vascular tone. NO and H 2 S are …

Regulation of blood pressure by natural sulfur compounds: Focus on their mechanisms of action

E Piragine, V Citi, K Lawson, V Calderone… - Biochemical …, 2022 - Elsevier
Natural sulfur compounds are emerging as therapeutic options for the management of
hypertension and prehypertension. They are mainly represented by polysulfides from …

Beyond a gasotransmitter: hydrogen sulfide and polysulfide in cardiovascular health and immune response

S Yuan, X Shen, CG Kevil - Antioxidants & Redox Signaling, 2017 - liebertpub.com
Abstract Significance: Hydrogen sulfide (H2S) metabolism leads to the formation of oxidized
sulfide species, including polysulfide, persulfide, and others. Evidence is emerging that …