[HTML][HTML] New opportunities and challenges of natural products research: When target identification meets single-cell multiomics

Y Zhu, Z Ouyang, H Du, M Wang, J Wang, H Sun… - … Pharmaceutica Sinica B, 2022 - Elsevier
Natural products, and especially the active ingredients found in traditional Chinese medicine
(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in …

[HTML][HTML] Dietary polyphenol, gut microbiota, and health benefits

X Wang, Y Qi, H Zheng - Antioxidants, 2022 - mdpi.com
Polyphenols, which are probably the most important secondary metabolites produced by
plants, have attracted tremendous attention due to their health-promoting effects, including …

Oral polyphenol-armored nanomedicine for targeted modulation of gut microbiota–brain interactions in colitis

H He, Q Qin, F Xu, Y Chen, S Rao, C Wang, X Jiang… - Science …, 2023 - science.org
Developing oral nanomedicines that suppress intestinal inflammation while modulating gut
microbiota and brain interactions is essential for effectively treating inflammatory bowel …

Clostridium butyricum and its derived extracellular vesicles modulate gut homeostasis and ameliorate acute experimental colitis

L Ma, Q Shen, W Lyu, L Lv, W Wang, M Yu… - Microbiology …, 2022 - Am Soc Microbiol
Microbiological treatments are expected to have a role in the future management of
inflammatory bowel disease (IBD). Clostridium butyricum (C. butyricum) is a probiotic …

Polyphenols from Fu brick tea reduce obesity via modulation of gut microbiota and gut microbiota-related intestinal oxidative stress and barrier function

F Zhou, YL Li, X Zhang, KB Wang… - Journal of Agricultural …, 2021 - ACS Publications
Fu brick tea (FBT) is a microbial-fermented tea, which is produced by the solid-state
fermentation of tea leaves. Previous studies have proved that FBT aqueous extracts could …

[HTML][HTML] Gut microbiota remodeling improves natural aging-related disorders through Akkermansia muciniphila and its derived acetic acid

J Ma, Z Liu, X Gao, Y Bao, Y Hong, X He, W Zhu… - Pharmacological …, 2023 - Elsevier
Accumulating evidence indicates gut microbiota contributes to aging-related disorders.
However, the exact mechanism underlying gut dysbiosis-related pathophysiological …

Interactions between gut microbiota and polyphenols: A mechanistic and metabolomic review

H Cheng, D Zhang, J Wu, J Liu, Y Zhou, Y Tan, W Feng… - Phytomedicine, 2023 - Elsevier
Background Polyphenols are a class of naturally sourced compounds with widespread
distribution and an extensive array of bioactivities. However, due to their complex …

[HTML][HTML] The role of Akkermansia muciniphila in inflammatory bowel disease: Current knowledge and perspectives

M Zheng, R Han, Y Yuan, Y Xing, W Zhang… - Frontiers in …, 2023 - frontiersin.org
Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, is a chronic
relapsing gastrointestinal inflammatory disease mediated by dysregulated immune …

Gut microbiota participates in polystyrene microplastics-induced hepatic injuries by modulating the gut–liver axis

K Zhang, J Yang, L Chen, J He, D Qu, Z Zhang, Y Liu… - ACS …, 2023 - ACS Publications
Dietary pollution by polystyrene microplastics (MPs) can cause hepatic injuries and
microbial dysbiosis. Epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea …

[HTML][HTML] Crosstalk between gut microbiota and host immunity: impact on inflammation and immunotherapy

C Campbell, MR Kandalgaonkar, RM Golonka… - Biomedicines, 2023 - mdpi.com
Gut microbes and their metabolites are actively involved in the development and regulation
of host immunity, which can influence disease susceptibility. Herein, we review the most …