Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …

Platelets are anucleate cytoplasmic fragments derived from the fragmentation of medullary
megakaryocytes. Activated platelets adhere to the damaged endothelium by means of …

Atherosclerosis is an inflammatory disease within the arterial wall that is responsible for
several important adverse vascular events, including coronary artery disease, myocardial …

The recognition that atherosclerosis is a complex chronic inflammatory disorder mediated
through both adaptive and innate immunity has led to the hypothesis that anticytokine …

Background Disrupting the costimulatory CD40-CD40L dyad reduces atherosclerosis, but
can result in immune suppression. The authors recently identified small molecule inhibitors …

It has become clear that platelets are not simply cell fragments that plug the leak in a
damaged blood vessel; they are, in fact, also key components in the innate immune system …

Atherosclerosis is a chronic progressive inflammatory disease of the large and medium-
sized artery walls. The molecular mechanisms regulating the onset and progression of …

Objective Patients with inflammatory bowel disease (IBD) are at increased risk of having
venous thromboembolism. The magnitude of this risk has yet to be determined. The question …

Atherosclerosis is a major underlying cause of cardiovascular disease. Previous studies
showed that inhibition of the co-stimulatory CD40 ligand (CD40L)-CD40 signaling axis …

The pathology of cardiovascular disease (CVD) is complex; multiple biological pathways
have been implicated, including, but not limited to, inflammation and oxidative stress …