The Keap1-Nrf2-ARE pathway is one of the most important regulators of cytoprotective
responses to oxidative and/or electrophilic stresses, which is believed to play a critical role …

We report herein the design and synthesis of bioisosteres of spirooxindole (MI-63/219), a
small-molecule inhibitors of the MDM2–p53 interaction as anti-breast cancer agents …

Cellular tumor antigen p53 is significant for cancer prevention and its mutation is most
documented genomic change in human cancers. Thus, restoration of p53 function by …

We previously reported the discovery of potent and selective morpholinone and
piperidinone inhibitors of the MDM2-p53 interaction. These inhibitors have in common a …

An efficient synthetic methodology for the preparation of 3-amino 1, 5-dihydro-2 H-pyrrol-2-
ones through a multicomponent reaction of amines, aldehydes, and pyruvate derivatives is …

We report efficient synthetic methodologies for the preparation of 3-amino and 3-hydroxy 3-
pyrrolin-2-ones (unsaturated γ-lactams) through a multicomponent reaction of amines …

Restoring p53 levels through disruption of p53–MDM2 interaction has been proved to be a
valuable approach in fighting cancer. We herein report the synthesis and evaluation of …

Owing to their structural novelty and inherent three-dimensionality, spiro scaffolds have
been shown indisputable promise as chemopreventive agents. A new series of heterocycles …

Chiral phosphoric acids are efficient organocatalysts for the asymmetric three-component
reaction of amines, aldehydes, and pyruvate derivatives. Simultaneous condensation of …

The tumor suppressor protein p53 is often called “the genome guardian” and controls the
cell cycle and the integrity of DNA, as well as other important cellular functions. Its main …