Owing to their structural novelty and inherent three-dimensionality, spiro scaffolds have
been shown indisputable promise as chemopreventive agents. A new series of heterocycles …

Rational design for a new spiroxindoles, combined with a benzimidazole scaffold to identify
a new murine double minute two (MDM2) inhibitor was synthesized and characterized. The …

The tumor suppressor protein p53 is often called “the genome guardian” and controls the
cell cycle and the integrity of DNA, as well as other important cellular functions. Its main …

Simultaneous inactivation of p53 and hyperactivation of nuclear factor-κB (NF-κB) is a
common occurrence in human cancer. Currently, antitumor agents are being designed to …

Abstract Generation of 3-sulfonated 2H-pyrrol-2-ones through a three-component reaction of
allenoic amides, sulfur dioxide, and aryldiazonium tetrafluoroborates under metal-free …

Generation of multi-substituted pyrroles is accomplished through an unexpected iron (II)-
promoted reaction of N-arylprop-2-yn-1-imines with water. This transformation proceeds …

Colorectal cancer (CRC) is the third most detected cancer and the second foremost cause of
cancer deaths in the world. Intervention targeting p53 provides potential therapeutic …

Among the tumor suppressor genes, p53 is one of the most studied. It is widely regarded as
the “guardian of the genome”, playing a major role in carcinogenesis. In fact, direct …

Abstract An ytterbium catalyzed formal [3+ 3] cycloaddition of cyclic enamines and α, β‐
unsaturated ketones catalyzed is reported. The reaction proceeds with a 'head to …

An enantioselective [4+ 2] cyclization reaction of dioxopyrrolidines and azlactones has been
successfully developed through a squaramide catalysis strategy. This protocol provides an …