Vaccines are one of the most effective public health tools to prevent and manage infectious
diseases. Since the first clinical use of vaccines in the late 18th century, many vaccines have …

Fungal infections represent a serious global health problem, causing damage to health and
the economy on the scale of millions. Although vaccines are the most effective therapeutic …

Systemic cryptococcosis is fatal without treatment. Even with the current antifungal therapies,
this disease kills 180,000 of 225,000 infected people annually. Exposure to the causative …

Systemic infection with Cryptococcus neoformans, a dangerous and contagious pathogen
found throughout the world, frequently results in lethal cryptococcal pneumonia and …

Cryptococcus neoformans is a ubiquitous soil fungus and airborne pathogen that causes
over 180,000 deaths each year. Cryptococcus must adapt to host CO2 levels to cause …

The environmental pathogen Cryptococcus neoformans claims over 180,000 lives each
year. Survival of this basidiomycete at host CO 2 concentrations has only recently been …

The Complex of Proteins Associated with Set1 (COMPASS) methylates lysine K4 on histone
H3 (H3K4) and is conserved from yeast to humans. Its subunits and regulatory roles in the …

Highlights•Morphotypes are defined as transcriptionally distinct, stable, heritable growth
types.•Cryptococcus neoformans exhibits at least three morphotypes relevant to …

Cryptococcosis is a mycosis caused by Cryptococcus neoformans and C. gattii species
complexes. Although this infection is potentially lethal, no prophylactic vaccine is yet …

Cryptococcus neoformans causes cryptococcal meningoencephalitis, a disease that kills
more than 180,000 people annually. Contributing to its success as a fungal pathogen is its …