Antimalarial drug resistance and novel targets for antimalarial drug discovery
MA Shibeshi, ZD Kifle, SA Atnafie - Infection and drug resistance, 2020 - Taylor & Francis
Malaria is among the most devastating and widespread tropical parasitic diseases in which
most prevalent in developing countries. Antimalarial drug resistance is the ability of a …
most prevalent in developing countries. Antimalarial drug resistance is the ability of a …
Comprehensive review on various strategies for antimalarial drug discovery
M Mishra, VK Mishra, V Kashaw, AK Iyer… - European journal of …, 2017 - Elsevier
The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …
limiting our ability to manage this severe disease and finally lead to a massive global health …
[HTML][HTML] Drug targets for resistant malaria: historic to future perspectives
New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …
Cerebral Malaria and Neuronal Implications of Plasmodium Falciparum Infection: From Mechanisms to Advanced Models
Reorganization of host red blood cells by the malaria parasite Plasmodium falciparum
enables their sequestration via attachment to the microvasculature. This artificially increases …
enables their sequestration via attachment to the microvasculature. This artificially increases …
[HTML][HTML] Malaria therapeutics: are we close enough?
Malaria is a vector-borne parasitic disease caused by the apicomplexan protozoan parasite
Plasmodium. Malaria is a significant health problem and the leading cause of …
Plasmodium. Malaria is a significant health problem and the leading cause of …
[HTML][HTML] Cysteine proteases: Battling pathogenic parasitic protozoans with omnipresent enzymes
Millions of people worldwide lie at the risk of parasitic protozoic infections that kill over a
million people each year. The rising inefficacy of conventional therapeutics to combat these …
million people each year. The rising inefficacy of conventional therapeutics to combat these …
Antimalarial activity of small-molecule benzothiazole hydrazones
We synthesized a new series of conjugated hydrazones that were found to be active against
malaria parasite in vitro, as well as in vivo in a murine model. These hydrazones …
malaria parasite in vitro, as well as in vivo in a murine model. These hydrazones …
Evaluation of In Vitro Antimalarial Activity of Different Extracts of Artemisia aucheri Boiss. and A. armeniaca Lam. and Fractions of the Most Potent Extracts
Ten extracts with different polarity from two Iranian Artemisia species, A. armeniaca Lam.
and A. aucheri Boiss, were screened for their antimalarial properties by in vitro β‐hematin …
and A. aucheri Boiss, were screened for their antimalarial properties by in vitro β‐hematin …
Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum
We have investigated the DNA-binding nature as well as the function of a putative Alba
(Acetylation lowers binding affinity) family protein (PfAlba3) from Plasmodium falciparum …
(Acetylation lowers binding affinity) family protein (PfAlba3) from Plasmodium falciparum …
Falcipains: biochemistry, target validation and structure-activity relationship studies of inhibitors as antimalarials
J Patra, D Rana, S Arora, M Pal, N Mahindroo - European Journal of …, 2023 - Elsevier
Malaria is a tropical disease with significant morbidity and mortality burden caused by
Plasmodium species in Africa, the Middle East, Asia, and South America. Pathogenic …
Plasmodium species in Africa, the Middle East, Asia, and South America. Pathogenic …