Antimalarial drug resistance and novel targets for antimalarial drug discovery

MA Shibeshi, ZD Kifle, SA Atnafie - Infection and drug resistance, 2020 - Taylor & Francis
Malaria is among the most devastating and widespread tropical parasitic diseases in which
most prevalent in developing countries. Antimalarial drug resistance is the ability of a …

Comprehensive review on various strategies for antimalarial drug discovery

M Mishra, VK Mishra, V Kashaw, AK Iyer… - European journal of …, 2017 - Elsevier
The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …

[HTML][HTML] Drug targets for resistant malaria: historic to future perspectives

S Kumar, TR Bhardwaj, DN Prasad… - Biomedicine & …, 2018 - Elsevier
New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …

Cerebral Malaria and Neuronal Implications of Plasmodium Falciparum Infection: From Mechanisms to Advanced Models

OB Akide Ndunge, N Kilian, MM Salman - Advanced Science, 2022 - Wiley Online Library
Reorganization of host red blood cells by the malaria parasite Plasmodium falciparum
enables their sequestration via attachment to the microvasculature. This artificially increases …

[HTML][HTML] Malaria therapeutics: are we close enough?

H Tripathi, P Bhalerao, S Singh, H Arya, BS Alotaibi… - Parasites & …, 2023 - Springer
Malaria is a vector-borne parasitic disease caused by the apicomplexan protozoan parasite
Plasmodium. Malaria is a significant health problem and the leading cause of …

[HTML][HTML] Cysteine proteases: Battling pathogenic parasitic protozoans with omnipresent enzymes

A Rawat, M Roy, A Jyoti, S Kaushik, K Verma… - Microbiological …, 2021 - Elsevier
Millions of people worldwide lie at the risk of parasitic protozoic infections that kill over a
million people each year. The rising inefficacy of conventional therapeutics to combat these …

Antimalarial activity of small-molecule benzothiazole hydrazones

S Sarkar, AA Siddiqui, SJ Saha, R De… - Antimicrobial agents …, 2016 - Am Soc Microbiol
We synthesized a new series of conjugated hydrazones that were found to be active against
malaria parasite in vitro, as well as in vivo in a murine model. These hydrazones …

Evaluation of In Vitro Antimalarial Activity of Different Extracts of Artemisia aucheri Boiss. and A. armeniaca Lam. and Fractions of the Most Potent Extracts

M Mojarrab, A Shiravand, A Delazar… - The Scientific World …, 2014 - Wiley Online Library
Ten extracts with different polarity from two Iranian Artemisia species, A. armeniaca Lam.
and A. aucheri Boiss, were screened for their antimalarial properties by in vitro β‐hematin …

Identification and molecular characterization of an Alba-family protein from human malaria parasite Plasmodium falciparum

M Goyal, A Alam, MS Iqbal, S Dey, S Bindu… - Nucleic acids …, 2012 - academic.oup.com
We have investigated the DNA-binding nature as well as the function of a putative Alba
(Acetylation lowers binding affinity) family protein (PfAlba3) from Plasmodium falciparum …

Falcipains: biochemistry, target validation and structure-activity relationship studies of inhibitors as antimalarials

J Patra, D Rana, S Arora, M Pal, N Mahindroo - European Journal of …, 2023 - Elsevier
Malaria is a tropical disease with significant morbidity and mortality burden caused by
Plasmodium species in Africa, the Middle East, Asia, and South America. Pathogenic …