Hyaluronic acid (HA) is a large non-sulfated glycosaminoglycan that is the main component
of the extracellular matrix (ECM). Because of its strong and diversified functions applied in …

Immunotherapy has been increasingly used in the treatment of cancer. Compared with
chemotherapy, immunotherapy relies on the autoimmune system with fewer side effects …

Abstract Small diameter (< 6 mm) prosthetic vascular grafts continue to show very low long-
term patency, but bioengineered vascular grafts show promising results in preclinical …

Hydrogel is a nature scaffold that can degraded in animal body and can be used as a drug
delivery system, we hypothesized that patch made of three layers of hydrogel with different …

Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease that responds poorly to single-
drug immunotherapy with PD-L1 (CD274) inhibitors. Here, we prepared mesoporous …

Tissue-engineered plant scaffolds have shown promising applications in in vitro studies. To
assess the applicability of natural plant scaffolds as vascular patches, we tested …

Excessive proliferation of vascular smooth muscle cells (SMCs) remains a significant cause
of in-stent restenosis. Integrins, which are heterodimeric transmembrane receptors, play a …

Purpose The causes and pathogenetic mechanisms underlying abdominal aortic aneurysms
(AAAs) and pseudoaneurysms are not fully understood. We hypothesized that inhibiting …

Introduction: We recently showed that a decellularized leaf scaffold can be loaded with
polylactic-co-glycolic acid (PLGA)-based rapamycin nanoparticles, this leaf patch can then …

Objectives Aneurysms are generally the result of dilation of all 3 layers of the vessel wall,
and pseudoaneurysms are the result of localized extravasation of blood that is contained by …