Contributions of the 9-Layered Model of Giftedness to the Development of a Conversational Agent for Healthy Ageing and Sustainable Living

M Karyotaki, A Drigas, C Skianis - Sustainability, 2024 - mdpi.com
The 9-Layered Model of Giftedness is an innovative conceptual framework composed of an
integrated set of abilities, skills and values that align with Goals 3, 4 and 8 of the UN …

[HTML][HTML] Taste-immune associative learning amplifies immunopharmacological effects and attenuates disease progression in a rat glioblastoma model

S Hetze, L Barthel, L Lückemann, HS Günther… - Brain, Behavior, and …, 2022 - Elsevier
Mechanistic target of rapamycin (mTOR)-signaling is one key driver of glioblastoma (GBM),
facilitating tumor growth by promoting the shift to an anti-inflammatory, pro-cancerogenic …

Aica development challenges

S Xu - Autonomous Intelligent Cyber Defense Agent (AICA) A …, 2023 - Springer
In this chapter we explore the development challenges that must be tackled before fulfilling
the great potential of Autonomous Intelligent Cyberdefense Agent (AICA). We propose …

Systemic and local regulation of hematopoietic homeostasis in health and disease

RS Carpenter, M Maryanovich - Nature Cardiovascular Research, 2024 - nature.com
Hematopoietic stem cells (HSCs) generate all blood cell lineages responsible for tissue
oxygenation, life-long hematopoietic homeostasis and immune protection. In adulthood …

LRRK2 Inhibition by PF06447475 Antagonist Modulates Early Neuronal Damage after Spinal Cord Trauma

A Filippone, D Mannino, L Cucinotta, I Paterniti… - Antioxidants, 2022 - mdpi.com
Spinal cord injury (SCI) is a devastating event followed by neurodegeneration, activation of
the inflammatory cascade, and immune system. The leucine-rich-repeat kinase 2 (LRRK2) is …

Brain-Splenic Immune System Interactions in Hypertension: Cellular and Molecular Mechanisms

S Perrotta, D Carnevale - Arteriosclerosis, Thrombosis, and …, 2024 - Am Heart Assoc
Hypertension represents a major worldwide cause of death and disability, and it is becoming
increasingly clear that available therapies are not sufficient to reduce the risk of major …

Carbohydrates Metabolic Signatures in Immune Cells: Response to Infection

K Awad, AS Maghraby, DN Abd-Elshafy… - Frontiers in …, 2022 - frontiersin.org
Introduction Metabolic reprogramming in immune cells is diverse and distinctive in terms of
complexity and flexibility in response to heterogeneous pathogenic stimuli. We studied the …

Phasic firing of dopaminergic neurons in the ventral tegmental area triggers peripheral immune responses

T Kayama, Y Ikegaya, T Sasaki - Scientific reports, 2022 - nature.com
Dopaminergic neurons in the ventral tegmental area (VTA) play a crucial role in the
processing of reward-related information. Recent studies with pharmacological …

Cognitive functions are not reducible to biological ones: the case of minimal visual perception

A Arnellos, A Moreno - Biology & Philosophy, 2022 - Springer
We argue that cognitive functions are not reducible to biological functionality. Since only
neural animals can develop complex forms of agency, we assume that genuinely cognitive …

Exploration of the Noncoding Genome for Human-Specific Therapeutic Targets—Recent Insights at Molecular and Cellular Level

W Poller, S Sahoo, R Hajjar, U Landmesser… - Cells, 2023 - mdpi.com
While it is well known that 98–99% of the human genome does not encode proteins, but are
nevertheless transcriptionally active and give rise to a broad spectrum of noncoding RNAs …