Although cancer immunotherapy has emerged as a novel cancer treatment modality, it still
suffers from low therapeutic efficacy in clinics due to the presence of a low number of …

Anticancer drugs in monotherapy are ineffective to treat various kinds of cancer due to the
heterogeneous nature of cancer. Moreover, available anticancer drugs possessed various …

Over the last decades, nanotechnology applied in medicine (nanomedicine) has sparked
great interest from the scientific community, thanks to the possibility to engineer …

Peptide vaccines have shown great potential in cancer immunotherapy by targeting tumor
antigens and activating the patient's immune system to mount a specific response against …

Research into the application of nanocarriers in the delivery of cancer-fighting drugs has
been a promising research area for decades. On the other hand, their cytotoxic effects on …

Gene therapy with RNA and pDNA-based drugs is limited by poor enzymatic stability and
poor cellular permeation. The delivery of nucleic acids, in particular by the oral route …

Drug delivery systems are believed to increase pharmaceutical efficacy and the therapeutic
index by protecting and stabilizing bioactive molecules, such as protein and peptides …

Nanoparticles represent a potent antigen presentation and delivery system to elicit an
optimal immune response by effector cells targeting tumor-associated antigens expressed …

In the last years the rapid development of Nucleic Acid Based Drugs (NABDs) to be used in
gene therapy has had a great impact in the medical field, holding enormous promise …

To achieve the promise of stimuli-responsive drug delivery systems for the treatment of
cancer, they should (1) avoid premature clearance;(2) accumulate in tumors and undergo …