Clinical and laboratory studies over recent decades have established branched evolution as
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …

Cancer is a leading cause of death worldwide and, despite new targeted therapies and
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …

A quintessential setting for precision medicine, theranostics refers to a rapidly evolving field
of medicine in which disease is diagnosed followed by treatment of disease‐positive …

Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer
evolution studies, providing insight into the clonality and relative ordering of mutations and …

Cancer is a complex disease that is associated with genetic aberrations and subsequent
cellular and noncellular host responses. Tumors harbor diverse cell types that engage in a …

Bioresponsive polymers have been widely used in drug delivery because of their
degradability. For example, poly (disulfide) s with repeating disulfide bonds in the main …

Simple Summary In breast cancer, there is a high degree of variability in tumors and the
surrounding tissue called the tumor microenvironment (TME). To better understand tumor …

The evolution and progression of multiple myeloma and its precursors over time is poorly
understood. Here, we investigate the landscape and timing of mutational processes shaping …

Over the last decade, precision medicine and immunotherapeutic approaches have become
increasingly popular in oncology. Early clinical trials reported promising results, but …

Patients treated with cytotoxic therapies, including autologous stem cell transplantation, are
at risk for developing therapy-related myeloid neoplasms (tMN). Preleukemic clones (ie …