Transposition of great arteries (TGA) is one of the most common and severe congenital heart
diseases (CHD). It is also one of the most mysterious CHD because it has no precedent in …

Congenital heart disease (CHD) is the most common major congenital anomaly with an
incidence of∼ 1% of live births and is a significant cause of birth defect–related mortality …

Congenital heart disease (CHD) is the most common type of birth defect. Traditionally, a
polygenic model defined by the interaction of multiple genes and environmental factors was …

Objective To evaluate the effectiveness of nuchal translucency (NT) measurement in
screening for major congenital heart disease (CHD) in chromosomally normal fetuses …

Congenital heart defects (CHDs) are the most common major developmental anomalies and
the most frequent cause for perinatal mortality, but their etiology remains often obscure. We …

Congenital heart malformation (CHM) is the most common form of congenital human birth
anomaly and is the leading cause of infant mortality. Although some causative genes have …

Mutations in TBX5, a T-box–containing transcription factor, cause cardiac and limb
malformations in individuals with Holt-Oram syndrome (HOS). Mutations that result in …

We conducted a genome-wide association study to search for risk alleles associated with
Tetralogy of Fallot (TOF), using a northern European discovery set of 835 cases and 5159 …

Objective: To determine in women with surgically corrected tetralogy of Fallot the risk of
pregnancy for mother and fetus, whether fertility was compromised, and the recurrence risk …

Deletions in the distal region of chromosome 8p (del8p) are associated with congenital heart
malformations. Other major manifestations include microcephaly, intrauterine growth …