CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Other than serving as building blocks for DNA and RNA, purine metabolites provide a cell
with the necessary energy and cofactors to promote cell survival and proliferation. A …

Lenalidomide is a highly effective treatment for myelodysplastic syndrome (MDS) with
deletion of chromosome 5q (del (5q)). Here, we demonstrate that lenalidomide induces the …

To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …

The hypothalamic paraventricular nucleus (PVN) is a unique and important brain region
involved in the control of cardiovascular, neuroendocrine, and other physiological functions …

Selective degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is
initiated by ER-phagy receptors, which facilitate the incorporation of ER fragments into …

Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by
genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine …

Chronic lymphocytic leukemia (CLL) is an incurable malignancy of B-cells. In this study,
bioinformatics analyses were conducted to identify possible pathogenic roles of CK2α …

Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key
regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation …

Plants have evolved complex systems to rapidly respond to severe stress conditions, such
as heat, cold, and dehydration. Dehydration-responsive element-binding protein 2A …