As a permanent state of cell cycle arrest, cellular senescence has become an important
factor in aging and age-related diseases. As a central regulator of physiology and pathology …

An important mechanism for the development of intervertebral disc degeneration (IDD) is an
imbalance between anti-inflammatory and pro-inflammatory cytokines. Therapeutic and non …

Background The N6‐methyladenosine (m6A) dynamics in the progression of intervertebral
disc (IVD) aging remain largely unknown. This study aimed to explore the distribution and …

Background/Aim: In the literature, the studies about the role of matrix metalloproteinase-2
(MMP-2) in pterygium diagnosis are mainly based on its protein expression. The role of …

Abstract Background Although Klotho-related research has seen a significant upsurge, the
field lacks comprehensive analytical representation and in-depth exploration of pertinent …

To explore the relationship between diabetes and intervertebral disc degeneration in mice
and the associated underlying mechanism. Four-week-old male Kunming mice were used to …

AbstractObjective: This study aims to explore the relationship between dietary folate intake
and serum Klotho levels in adults from aged 40 to 79 years in the United States, seeking to …

Mechanical environment worsening is an important predisposing factor that accelerates
intervertebral disc degeneration (IDD), but its specific regulatory mechanisms remain …

Abstract Yippee-like 2 (YPEL2) is expressed in tissues and organs enriched in vascular
networks, such as heart, kidney, and lung. However, the roles of YPEL2 in endothelial cell …

Aim: Herein, we plan to explore the potential mechanism between intervertebral disc
degeneration (IDD) and FUBP1 in reactive oxygen species mitochondria. Methods: IDD …