Allergies, including asthma, food allergy and atopic dermatitis, are increasing in prevalence,
particularly in westernized countries. Although a detailed mechanistic explanation for this …

Monocytes and macrophages are central players of the innate immune response and play a
pivotal role in the regulation of inflammation. Thereby, they actively participate in all phases …

Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. Sepsis can induce acute kidney injury and multiple organ failures …

Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …

Macrophages are first responders for the immune system. In this role, they have both effector
functions for neutralizing pathogens and sentinel functions for alerting other immune cells of …

Major depression is a prevalent illness that increases the risk of several neurological
conditions. These include stroke, cardiovascular disease, and dementia including …

Background Increasing evidence suggests that gut microbiota play a role in the
pathogenesis of breast cancer. The composition and functional capacity of gut microbiota …

Macrophages are activated during microbial infection to coordinate inflammatory responses
and host defense. Here we find that in macrophages activated by bacterial …

Adaptation is the ability of cells, tissues and organisms to rapidly and reversibly modify their
properties to maximize fitness in a changing environment. The activity of immune-system …

Transcriptional memory is characterized by a primed cellular state, induced by an external
stimulus that results in an altered expression of primed genes upon re-exposure to the …