[HTML][HTML] Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments
Nowadays, diabetes mellitus has emerged as a significant global public health concern with
a remarkable increase in its prevalence. This review article focuses on the definition of …
a remarkable increase in its prevalence. This review article focuses on the definition of …
[HTML][HTML] Therapeutic Potential of Hibiscus sabdariffa Linn. in Attenuating Cardiovascular Risk Factors
S Sapian, AA Ibrahim Mze, FF Jubaidi, NA Mohd Nor… - Pharmaceuticals, 2023 - mdpi.com
Cardiovascular diseases (CVDs) represent a broad spectrum of diseases afflicting the heart
and blood vessels and remain a major cause of death and disability worldwide. CVD …
and blood vessels and remain a major cause of death and disability worldwide. CVD …
Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and …
Although the great effectiveness of doxorubicin (Dox) in the treatment of many types of
tumors, it showed limited effectiveness against the head and neck squamous cell carcinoma …
tumors, it showed limited effectiveness against the head and neck squamous cell carcinoma …
[HTML][HTML] The role of IL-13 and IL-4 in adipose tissue fibrosis
L Arndt, A Lindhorst, J Neugebauer… - International Journal of …, 2023 - mdpi.com
White adipose tissue (WAT) fibrosis, characterized by an excess of extracellular (ECM)
matrix components, is strongly associated with WAT inflammation and dysfunction due to …
matrix components, is strongly associated with WAT inflammation and dysfunction due to …
[HTML][HTML] Extracellular Matrix Proteomics: The mdx-4cv Mouse Diaphragm as a Surrogate for Studying Myofibrosis in Dystrophinopathy
P Dowling, S Gargan, M Zweyer, D Swandulla… - Biomolecules, 2023 - mdpi.com
The progressive degeneration of the skeletal musculature in Duchenne muscular dystrophy
is accompanied by reactive myofibrosis, fat substitution, and chronic inflammation. Fibrotic …
is accompanied by reactive myofibrosis, fat substitution, and chronic inflammation. Fibrotic …
[HTML][HTML] The Role of Genetic and Epigenetic Regulation in Intestinal Fibrosis in Inflammatory Bowel Disease: A Descending Process or a Programmed Consequence?
S Jarmakiewicz-Czaja, A Sokal, K Ferenc, E Motyka… - Genes, 2023 - mdpi.com
Inflammatory bowel diseases (IBDs) are a group of chronic diseases characterized by
recurring periods of exacerbation and remission. Fibrosis of the intestine is one of the most …
recurring periods of exacerbation and remission. Fibrosis of the intestine is one of the most …
Antioxidant therapy against TGF‐β/SMAD pathway involved in organ fibrosis
Fibrosis refers to excessive build‐up of scar tissue and extracellular matrix components in
different organs. In recent years, it has been revealed that different cytokines and …
different organs. In recent years, it has been revealed that different cytokines and …
[HTML][HTML] Novel Therapeutic Approaches to Liver Fibrosis Based on Targeting Oxidative Stress
A Blas-García, N Apostolova - Antioxidants, 2023 - mdpi.com
Chronic liver disease (CLD) constitutes a growing global health issue, with no effective
treatments currently available. Oxidative stress closely interacts with other cellular and …
treatments currently available. Oxidative stress closely interacts with other cellular and …
[HTML][HTML] Potential therapeutic targets of macrophages in inhibiting immune damage and fibrotic processes in musculoskeletal diseases
J Zhu, J Fan, Y Xia, H Wang, Y Li, C Fu - Frontiers in Immunology, 2023 - frontiersin.org
Macrophages are a heterogeneous cell type with high plasticity, exhibiting unique activation
characteristics that modulate the progression and resolution of diseases, serving as a key …
characteristics that modulate the progression and resolution of diseases, serving as a key …
[HTML][HTML] Hepatoprotective effects of biochanin a on thioacetamide-induced liver cirrhosis in experimental rats
The protective effect of biochanin A (BCA) on the histopathology, immunohistochemistry,
and biochemistry of thioacetamide (TAA)-induced liver cirrhosis in vivo was investigated …
and biochemistry of thioacetamide (TAA)-induced liver cirrhosis in vivo was investigated …