[HTML][HTML] Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments

SA Antar, NA Ashour, M Sharaky, M Khattab… - Biomedicine & …, 2023 - Elsevier
Nowadays, diabetes mellitus has emerged as a significant global public health concern with
a remarkable increase in its prevalence. This review article focuses on the definition of …

[HTML][HTML] Therapeutic Potential of Hibiscus sabdariffa Linn. in Attenuating Cardiovascular Risk Factors

S Sapian, AA Ibrahim Mze, FF Jubaidi, NA Mohd Nor… - Pharmaceuticals, 2023 - mdpi.com
Cardiovascular diseases (CVDs) represent a broad spectrum of diseases afflicting the heart
and blood vessels and remain a major cause of death and disability worldwide. CVD …

Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and …

AA Al-Karmalawy, M Rashed, M Sharaky… - European Journal of …, 2023 - Elsevier
Although the great effectiveness of doxorubicin (Dox) in the treatment of many types of
tumors, it showed limited effectiveness against the head and neck squamous cell carcinoma …

[HTML][HTML] The role of IL-13 and IL-4 in adipose tissue fibrosis

L Arndt, A Lindhorst, J Neugebauer… - International Journal of …, 2023 - mdpi.com
White adipose tissue (WAT) fibrosis, characterized by an excess of extracellular (ECM)
matrix components, is strongly associated with WAT inflammation and dysfunction due to …

[HTML][HTML] Extracellular Matrix Proteomics: The mdx-4cv Mouse Diaphragm as a Surrogate for Studying Myofibrosis in Dystrophinopathy

P Dowling, S Gargan, M Zweyer, D Swandulla… - Biomolecules, 2023 - mdpi.com
The progressive degeneration of the skeletal musculature in Duchenne muscular dystrophy
is accompanied by reactive myofibrosis, fat substitution, and chronic inflammation. Fibrotic …

[HTML][HTML] The Role of Genetic and Epigenetic Regulation in Intestinal Fibrosis in Inflammatory Bowel Disease: A Descending Process or a Programmed Consequence?

S Jarmakiewicz-Czaja, A Sokal, K Ferenc, E Motyka… - Genes, 2023 - mdpi.com
Inflammatory bowel diseases (IBDs) are a group of chronic diseases characterized by
recurring periods of exacerbation and remission. Fibrosis of the intestine is one of the most …

Antioxidant therapy against TGF‐β/SMAD pathway involved in organ fibrosis

S Ghafouri‐Fard, A Askari, H Shoorei… - Journal of Cellular …, 2024 - Wiley Online Library
Fibrosis refers to excessive build‐up of scar tissue and extracellular matrix components in
different organs. In recent years, it has been revealed that different cytokines and …

[HTML][HTML] Novel Therapeutic Approaches to Liver Fibrosis Based on Targeting Oxidative Stress

A Blas-García, N Apostolova - Antioxidants, 2023 - mdpi.com
Chronic liver disease (CLD) constitutes a growing global health issue, with no effective
treatments currently available. Oxidative stress closely interacts with other cellular and …

[HTML][HTML] Potential therapeutic targets of macrophages in inhibiting immune damage and fibrotic processes in musculoskeletal diseases

J Zhu, J Fan, Y Xia, H Wang, Y Li, C Fu - Frontiers in Immunology, 2023 - frontiersin.org
Macrophages are a heterogeneous cell type with high plasticity, exhibiting unique activation
characteristics that modulate the progression and resolution of diseases, serving as a key …

[HTML][HTML] Hepatoprotective effects of biochanin a on thioacetamide-induced liver cirrhosis in experimental rats

MY Ibrahim, ZZ Alamri, ASM Juma, SA Hamood… - Molecules, 2023 - mdpi.com
The protective effect of biochanin A (BCA) on the histopathology, immunohistochemistry,
and biochemistry of thioacetamide (TAA)-induced liver cirrhosis in vivo was investigated …