The natural history of cancers can be understood through the lens of evolution given that the
driving forces of cancer development are mutation and selection of fitter clones. Cancer …

A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to developing more efficient cancer detection methods and …

Heterogeneity within a tumour increases its ability to adapt to constantly changing
constraints, but adversely affects a patient's prognosis, therapy response and clinical …

Clinical and laboratory studies over recent decades have established branched evolution as
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …

As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Breast cancer is a heterogeneous disease and differs greatly among different patients
(intertumor heterogeneity) and even within each individual tumor (intratumor heterogeneity) …

For over six decades reductionist approaches to cancer chemotherapies including recent
immunotherapy for solid tumors produced outcome failure-rates of 90%(±5) according to …

Despite the abundant ongoing research efforts, cancer remains one of the most challenging
diseases to treat globally. Due to the heterogenous nature of cancer, one of the major …

Breast cancer is the most common cancer among women worldwide. Due to its complexity in
nature, effective breast cancer treatment can encounter many challenges. Traditional …