We have demonstrated chromosomal instability in the clonal descendants of hemopoietic
stem cells after irradiating murine bone marrow with α-particles. However, because cells that …

Purposes: To review research progress on the molecular mechanisms of low dose ionizing
radiation (LDIR)-induced hormesis, adaptive responses, radioresistance, bystander effects …

The mechanism (s) by which α particles like those emitted from inhaled radon and radon
progeny cause their mutagenic and carcinogenic effects remains unclear. Although direct …

Bystander responses have been reported to be a major determinant of the response of cells
to radiation exposure at low doses, including those of relevance to therapy. In this study …

The paradigm of genetic alterations being restricted to direct DNA damage after exposure to
ionizing radiation has been challenged by observations in which cells that are not exposed …

This study investigated the ability of medium from irradiated cells to induce early events in
the apoptotic cascade, such as mobilization of intracellular calcium, loss of mitochondrial …

Abstract Sawant, SG, Randers-Pehrson, G., Geard, CR, Brenner, DJ and Hall, EJ The
Bystander Effect in Radiation Oncogenesis: I. Transformation in C3H 10T½ Cells In Vitro can …

Abstract Seymour, CB and Mothersill, C. Relative Contribution of Bystander and Targeted
Cell Killing to the Low-Dose Region of the Radiation Dose–Response Curve. Human …

We examined the induction of HPRT mutations in CHO cells exposed to low fluences of α
particles from a specially constructed irradiator. The dose-response relationship was linear …

The radiation-induced bystander effect (RIBE) increases the probability of cellular response
and therefore has important implications for cancer risk assessment following low-dose …