Purpose: To review studies of radiation-induced genomic instability in haemopoietic cells.
Major findings: Studies have demonstrated a high frequency of non-clonal, cytogenetic …

Cigarette smoking and residential radon are, respectively, the first and second leading
cause of lung cancer in the United States today. Of the approximately 157 000 lung deaths …

Computational simulations, such as Monte Carlo track structure simulations, offer a powerful
tool for quantitatively investigating radiation interactions within cells. The modelling of the …

Although Radon (Rn) is a known agent for lung cancer, the link between Rn exposure and
other non-pulmonary neoplasms remains unclear. The aim of this review is to investigate the …

Radiation-induced bystander effects have been extensively studied at low doses, since
evidence of bystander induced cell killing and other effects on unirradiated cells were found …

A new in vitro multicellular cluster model has been developed to assess the impact of
nonuniform distributions of radioactivity on the biological response of mammalian cells, and …

We have previously shown that when confluent cultures of mammalian cells are exposed to
very low fluences of alpha particles, fluences whereby as few as 1% of the cell nuclei are …

Genomic instability and the bystander effect have recently been linked experimentally. It has
previously been shown that medium from irradiated cells can induce early events in the …

Available data suggesting the occurrence of “bystander effects”(ie damage induction in cells
not traversed by radiation) were collected and critically evaluated, in view of the …

A ureter primary explant technique, using porcine tissue sections was developed to study
bystander effects under in vivo like conditions where dividing and differentiated cells are …