Controlled biodegradability of polymers—a key to drug delivery systems

J Kopeček - Biomaterials, 1984 - Elsevier
By combining oligopeptide sequences with synthetic polymeric chains, carriers of drug
models can be prepared. The drug model (p-nitroaniline) is cleaved from the carrier in the …

[HTML][HTML] Chemistry routes for copolymer synthesis containing PEG for targeting, imaging, and drug delivery purposes

K Rahme, N Dagher - Pharmaceutics, 2019 - mdpi.com
Polyethylene glycol (PEG) is one of the most frequently used polymers for coating
nanocarriers to enhance their biocompatibility, hydrophilicity, stability, and biodegradability …

Polymer–drug conjugates: present state of play and future perspectives

X Pang, HL Du, HQ Zhang, YJ Zhai, GX Zhai - Drug discovery today, 2013 - Elsevier
Highlights•Polymer–drug conjugates provide a new platform for drug discovery.•We discuss
recent advances in five key classes of polymer–drug conjugates.•Promising approaches to …

[HTML][HTML] Stimuli-responsive polyprodrug for cancer therapy

C Lin, Y Liang, M Guo, PE Saw, X Xu - Materials Today Advances, 2022 - Elsevier
Cancer has posed an enormous challenge to human health. To enhance cancer therapy,
researchers have constructed the polyprodrug which drug molecules and polymer backbone …

Antitumor activity of β-Cyclodextrin polymer− camptothecin conjugates

J Cheng, KT Khin, ME Davis - Molecular pharmaceutics, 2004 - ACS Publications
Antitumor activity of linear, β-cyclodextrin polymer (CDP)− camptothecin (CPT) conjugates
(HGGG6, LGGG10, HG6, and HGGG10) is investigated in nude mice bearing human …

Stimuli-responsive self-assembled polymer nanoparticles for the oral delivery of antibodies

MK Miller, FA Chapa-Villarreal, HF Oldenkamp… - Journal of Controlled …, 2023 - Elsevier
Currently, commercially available antibody therapies must be delivered via parenteral
administration. Oral delivery of antibodies could increase patient compliance and improve …

Pendent chain functionalized polyacetals that display pH-dependent degradation: A platform for the development of novel polymer therapeutics

R Tomlinson, M Klee, S Garrett, J Heller… - …, 2002 - ACS Publications
The synthetic polymers that are used to prepare polymer therapeutics reaching clinical use
are predominantly nonbiodegradable, and this severely limits the molecular weight range …

Factors Controlling Degradation of Biologically Relevant Synthetic Polymers in Solution and Solid State

J Brito, AK Andrianov, SA Sukhishvili - ACS Applied Bio Materials, 2022 - ACS Publications
The field of biodegradable synthetic polymers, which is central for regenerative engineering
and drug delivery applications, encompasses a multitude of hydrolytically sensitive …

Exploring the potential of polymeric membranes in cutting-edge chemical and biomedical applications: A review

G Hazarika, SV Jadhav, PG Ingole - Materials Today Communications, 2024 - Elsevier
The integration of polymeric membranes as advanced materials in chemical and medical
applications has ignited substantial advancements across multiple domains. This review …

Stability in rat plasma and serum of lysosomally degradable oligopeptide sequences in N-(2-hydroxypropyl) methacrylamide copolymers

P Rejmanova, J Kopeček, R Duncan, JB Lloyd - Biomaterials, 1985 - Elsevier
Abstract Soluble copolymers of-(2-hydroxypropyl) methacrylamide (HPMA) were prepared
containing either oligopeptide side chains terminating in p-nitroaniline, or oligopeptide …