Vancomycin use is often associated with nephrotoxicity. It remains uncertain, however, to
what extent vancomycin is directly responsible, as numerous potential risk factors for acute …

Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection,
and it probably represents a pattern of response by the immune system to injury. A hyper …

Objectives To determine the existence of concentration–toxicity relationships for common β-
lactam antibiotic adverse effects and define thresholds above which toxicity is more likely …

Objectives: The objective of this systematic review and meta-analysis was to assess acute
kidney injury with combination therapy of vancomycin plus piperacillin-tazobactam, in …

Background: Recent studies have identified the combination of vancomycin with piperacillin-
tazobactam (VPT) to be associated with increased nephrotoxicity. Multiple, large cohort …

Vancomycin is the most frequently used antibiotic, accounting for up to 35% of hospitalized
patients with infection, because of its optimal bactericidal effectiveness and relatively low …

Study Objectives To determine whether the addition of piperacillin‐tazobactam leads to an
increased incidence of nephrotoxicity in patients receiving vancomycin and to explore …

Study Objective To evaluate the observed incidence of acute kidney injury (AKI) in adult
patients receiving either piperacillin‐tazobactam and vancomycin or cefepime‐vancomycin …

Background Serum procalcitonin (PCT) evaluation has been proposed for early diagnosis
and accurate staging and to guide decisions regarding patients with sepsis, severe sepsis …

Pseudomonas aeruginosa is characterized by a notable intrinsic resistance to antibiotics,
mainly mediated by the expression of inducible chromosomic β-lactamases and the …