Neutrophils, the most copious leukocytes in human blood, play a critical role in
tumorigenesis, cancer progression, and immune suppression. Recently, neutrophils have …

Immunotherapy has revolutionized the treatment in metastatic melanoma, but alternative
biomarkers that are economical, simple and reliable still need to be clarified. In this study …

Pretreatment neutrophil-to-lymphocyte ratio (NLR) has been reported to be associated with
the prognosis of inoperable gastric cancer patients with systemic therapy. However, no …

Background Systemic inflammation is important in the development of extrahepatic
cholangiocarcinoma (ECC). The aim of this study was to compare the prognostic power of …

Background Previous studies have suggested that an elevated baseline neutrophil-to-
lymphocyte ratio (BLNLR) and elevated relative change of NLR (ΔNLR%) is associated with …

We report a multicenter, phase 2 study evaluating the efficacy of pucotenlimab, an anti-PD-1
antibody, in patients with mismatch repair-deficient (dMMR) or microsatellite instability-high …

Background: The aim of this study was to systematically evaluate the prognostic role of
platelet lymphocyte ratio (PLR) in patients with melanoma through performing a meta …

In the field of advanced melanoma, there is an urgent need to investigate novel approaches
targeting specific components of the cancer–immunity cycle beyond immune checkpoint …

Abstract Background and Aim While studies continually identify new clinical prognostic
factors in stage IV melanoma, the introduction of targeted and immunotherapies have …

Merkel cell carcinomas (MCCs) are rare, aggressive, cutaneous neuroendocrine tumours,
approximately 80% of which are caused by the genomic integration of Merkel cell …