Transactivation of epidermal growth factor receptor by G protein-coupled receptors: recent progress, challenges and future research
Z Wang - International journal of molecular sciences, 2016 - mdpi.com
Both G protein-coupled receptors (GPCRs) and receptor-tyrosine kinases (RTKs) regulate
large signaling networks, control multiple cell functions and are implicated in many diseases …
large signaling networks, control multiple cell functions and are implicated in many diseases …
G protein‐coupled estrogen receptor‐selective ligands modulate endometrial tumor growth
WK Petrie, MK Dennis, C Hu, D Dai… - Obstetrics and …, 2013 - Wiley Online Library
Endometrial carcinoma is the most common cancer of the female reproductive tract.
GPER/GPR30 is a 7‐transmembrane spanning G protein‐coupled receptor that has been …
GPER/GPR30 is a 7‐transmembrane spanning G protein‐coupled receptor that has been …
Vascular inflammation and atherosclerosis: the role of estrogen receptors
Estrogen receptors mediate numerous favorable effects on cells and molecules implicated in
vascular inflammation and atherogenic process. However, harmful effects have also been …
vascular inflammation and atherogenic process. However, harmful effects have also been …
Deciphering the GPER/GPR30-agonist and antagonists interactions using molecular modeling studies, molecular dynamics, and docking simulations
D Méndez-Luna, M Martínez-Archundia… - Journal of …, 2015 - Taylor & Francis
The G-protein coupled estrogen receptor 1 GPER/GPR30 is a transmembrane seven-helix
(7TM) receptor involved in the growth and proliferation of breast cancer. Due to the absence …
(7TM) receptor involved in the growth and proliferation of breast cancer. Due to the absence …
Chemerin-induced arterial contraction is Gi-and calcium-dependent
DJ Ferland, ES Darios, RR Neubig, B Sjögren… - Vascular …, 2017 - Elsevier
Chemerin is an adipokine associated with increased blood pressure, and may link obesity
with hypertension. We tested the hypothesis that chemerin-induced contraction of the …
with hypertension. We tested the hypothesis that chemerin-induced contraction of the …
Gender differences in GRK2 in cardiovascular diseases and its interactions with estrogen
L Fu, J Adu-Amankwaah, L Sang… - … of Physiology-Cell …, 2023 - journals.physiology.org
G protein-coupled receptor kinase 2 (GRK2) is a multifunctional protein involved in
regulating G protein-coupled receptor (GPCR) and non-GPCR signaling in the body. In the …
regulating G protein-coupled receptor (GPCR) and non-GPCR signaling in the body. In the …
Understanding the molecular basis of agonist/antagonist mechanism of GPER1/GPR30 through structural and energetic analyses
The G-protein coupled receptors (GPCRs) represent the largest superfamily of membrane
proteins in charge to pass the cell signaling after binding with their cognate ligands to the …
proteins in charge to pass the cell signaling after binding with their cognate ligands to the …
The protective role of G protein-coupled estrogen receptor 1 (GPER-1) on methotrexate-induced nephrotoxicity in human renal epithelium cells
Nephrotoxicity is an important problem during methotrexate (MTX) treatment, which has
been widely used for the treatment of several cancer types. Females are less susceptible to …
been widely used for the treatment of several cancer types. Females are less susceptible to …
Do fasudil and Y-27632 affect the level of transient receptor potential (TRP) gene expressions in breast cancer cell lines?
B Gogebakan, R Bayraktar, A Suner, O Balakan… - Tumor Biology, 2014 - Springer
Breast cancer (BC) is the most frequent cancer type in women, and the mortality rate is high
especially in metastatic disease. Ion channels such as the transient receptor potential (TRP) …
especially in metastatic disease. Ion channels such as the transient receptor potential (TRP) …
A mimic of the tumor microenvironment on GPR30 gene expression in breast cancer
S Rasoulpoor, MR Asgharzadeh… - Multidisciplinary Cancer …, 2022 - mcijournal.com
Methods: The breast cancer MCF-7 and MDA-MB-231 cells were cultured with different
concentrations of glucose (5.5, 11, and 25 mM) under normoxia/hypoxia for 24, 48, and 72 …
concentrations of glucose (5.5, 11, and 25 mM) under normoxia/hypoxia for 24, 48, and 72 …