[HTML][HTML] Genetic insights into the neurobiology of anxiety
MK Koskinen, I Hovatta - Trends in Neurosciences, 2023 - cell.com
Anxiety and fear are evolutionarily conserved emotions that increase the likelihood of an
organism surviving threatening situations. Anxiety and vigilance states are regulated by …
organism surviving threatening situations. Anxiety and vigilance states are regulated by …
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …
than most other psychiatric disorders. The contribution to biological understanding from …
Beyond monoamines: I. Novel targets and radiotracers for Positron emission tomography imaging in psychiatric disorders
With the emergence of positron emission tomography (PET) in the late 1970s, psychiatry
had access to a tool capable of noninvasive assessment of human brain function. Early …
had access to a tool capable of noninvasive assessment of human brain function. Early …
Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood
The molecular pathology of stress-related disorders remains elusive. Our brain multiregion,
multiomic study of posttraumatic stress disorder (PTSD) and major depressive disorder …
multiomic study of posttraumatic stress disorder (PTSD) and major depressive disorder …
PTSD, major depression, and advanced transcriptomic age in brain tissue
Background Psychiatric disorders have been associated with advanced epigenetic age in
DNA methylation, yet this relationship has not been studied in the brain transcriptome. We …
DNA methylation, yet this relationship has not been studied in the brain transcriptome. We …
Single-nucleus transcriptome profiling of dorsolateral prefrontal cortex: mechanistic roles for neuronal gene expression, including the 17q21. 31 locus, in PTSD stress …
C Chatzinakos, CD Pernia… - American Journal of …, 2023 - Am Psychiatric Assoc
Objective: Multidisciplinary studies of posttraumatic stress disorder (PTSD) and major
depressive disorder (MDD) implicate the dorsolateral prefrontal cortex (DLPFC) in disease …
depressive disorder (MDD) implicate the dorsolateral prefrontal cortex (DLPFC) in disease …
[HTML][HTML] Mineralocorticoid receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted …
Abstract 'You can't roll the clock back and reverse the effects of experiences' Bruce McEwen
used to say when explaining how allostasis labels the adaptive process. Here we will for …
used to say when explaining how allostasis labels the adaptive process. Here we will for …
Supplementary pharmacotherapy for the behavioral abnormalities caused by stressors in humans, focused on post-traumatic stress disorder (Ptsd)
J Fessel - Journal of clinical medicine, 2023 - mdpi.com
Used as a supplement to psychotherapy, pharmacotherapy that addresses all of the known
metabolic and genetic contributions to the pathogenesis of psychiatric conditions caused by …
metabolic and genetic contributions to the pathogenesis of psychiatric conditions caused by …
Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders
Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …
than most other psychiatric disorders. The contribution to biological understanding from …
Inflammation in Posttraumatic Stress Disorder: Dysregulation or Recalibration?
K Patas, DG Baker, GP Chrousos… - Current …, 2024 - ingentaconnect.com
Despite ample experimental data indicating a role of inflammatory mediators in the
behavioral and neurobiological manifestations elicited by exposure to physical and …
behavioral and neurobiological manifestations elicited by exposure to physical and …