We are developing immunization strategies against cervical carcinoma and premalignant
disease, based on the use of recombinant Semliki Forest virus (SFV) encoding the …

Although the central nervous system (CNS) is often regarded as an immunologically
privileged site, it is well established that specific CNS immunoreactivity can be generated …

The association of carcinoma of the uterine cervix with human papillomavirus indicates that
vaccine strategies which target the virus could be useful in the control of disease …

Background: The production of the cytokine interferon gamma (IFN γ) by activated peripheral
blood mononuclear cells may be reduced in patients with invasive cervical carcinoma. This …

Peptide-based vaccines derived from the E7 protein of human papillomavirus (HPV) type 16
were developed to induce effective T cell responses against established cervical cancer, but …

Chimeric papillomavirus (PV) virus-like particles (VLPs) based on the bovine papillomavirus
type 1 (BPV-1) L1 protein were constructed by replacing the 23-carboxyl-terminal amino …

Studies of the immunology of papillomavirus infection have come of age. Synthetic virus-like
particles have been validated as vaccines for several animal papillomaviruses, and have …

Human papillomavirus (HPV) tumor disease is a critical public health problem worldwide,
especially in the developing countries. The recognized pathogenic function of E5, E6, and …

Gynecological cancers are a leading cause of mortality in women. CD8+ T cell immunity
largely correlates with enhanced survival, whereas inflammation is associated with poor …

Human papillomaviruses (HPVs) are a group of circular double-stranded DNA viruses,
showing severe tropism to mucosal tissues. A subset of HPVs, especially HPV16 and 18, are …