Effective targeting of vectors to tumor cells that have metastasized to multiple different tissue
sites remains a major challenge for gene therapy. Tumor-specific cytotoxic T lymphocytes …

Objectives: In an attempt to develop virus-like particles (VLPs) as experimental vaccine
against human papilloma virus (HPV)-induced tumours, the HPV16 E7 oncoprotein epitopes …

ABSTRACT The simian virus 40 (SV40) large tumor antigen (Tag) is a virus-encoded
oncoprotein which is the target of a strong cytotoxic T-lymphocyte (CTL) response. Three …

The persistence of the E7 oncoprotein in transformed cells in human papillomavirus (HPV)-
associated cervical cancer provides a tumour-specific antigen to which immunotherapeutic …

The development of synthetic peptide vaccines capable of inducing strong and protective T-
cell immunity has taken more than 20 years. Peptide vaccines come in many flavors and …

Human Papillomaviruses are viruses that infect the epithelial layers of the oral, rectal,
vaginal, and cervical mucosa. There is a causal link between the development of cervical …

The discovery of the association between infection by the human papillomavirus (HPV) and
the development of cervical cancer has been the foundation for establishing HPV as the …

Cervical cancer is the second leading cause of cancer death among women worldwide and
remains an important health problem for women, especially in underserved and minority …

E6/E7 oncogenes of high-risk human papilloma virus (HPV) subtypes are essential for the
development of certain types of cancers. However, these oncogenes are insufficient to …

MHC-I-restricted cytotoxic responses are considered a critical component of protective
immunity against viruses, including human immunodeficiency virus type 1 (HIV-1). CTLs …