Despite their toxicity, aminoglycosides continue to play a pivotal role in the management of
serious infections. Indeed, their toxicity has led to comparatively restrained usage, and as a …

The pharmacokinetics and pharmacodynamics of drugs are different in adult and paediatric
populations, the latter being particularly heterogeneous. These differences in …

Background and objective Clearance is an important pharmacokinetic concept for scaling
dosage, understanding the risks of drug-drug interactions and environmental risk …

Linked Articles This article is commented on in the editorial by Holford NHG and Anderson
BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685–7. doi …

Maturation of drug systemic clearance mechanisms during the postnatal period produces
dramatic and rapid changes in an infant's capacity to eliminate drugs. A tentative general …

The efficacy and toxicity of aminoglycosides show a strong direct positive relationship with
blood drug concentrations, therefore, therapy with aminoglycosides in adults is usually …

Sepsis remains a major cause of mortality and morbidity in neonates, and, as a
consequence, antibiotics are the most frequently prescribed drugs in this vulnerable patient …

Background Sepsis is common in neonates and is a major cause of morbidity and mortality.
Sixty percent of preterm neonates receive at least one antibiotic, and 43% of the antibiotics …

Background: A number of special issues must be considered when selecting simple, safe,
inexpensive, and effective antimicrobial regimens for treatment of neonatal sepsis in …

Population pharmacokinetic modelling, Monte Carlo simulation and semi-mechanistic
pharmacodynamic modelling are all tools that can be applied to personalize gentamicin …