The human cerebral cortex has tremendous cellular diversity. How different cell types are
organized in the human cortex and how cellular organization varies across species remain …

The neocortex is disproportionately expanded in human compared with mouse,, both in its
total volume relative to subcortical structures and in the proportion occupied by …

The cerebellar cortex is a well-studied brain structure with diverse roles in motor learning,
coordination, cognition and autonomic regulation. However, a complete inventory of …

During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …

Neurological complications have emerged as a significant cause of morbidity and mortality
in the ongoing COVID-19 pandemic. Beside respiratory insufficiency, many hospitalized …

BACKGROUND The human brain contains about 100 billion neurons, each of which makes
thousands of synaptic connections. Although individual neurons can themselves be …

The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex
of a mouse, but the possible differences in synaptic circuits between these species are still …

Although complex inflammatory-like alterations are observed around the amyloid plaques of
Alzheimer's disease (AD), little is known about the molecular changes and cellular …

Genome-wide association studies have discovered numerous genomic loci associated with
Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We …

Realizing the full utility of brain organoids to study human development requires
understanding whether organoids precisely replicate endogenous cellular and molecular …