INTRODUCTION The brain is the most complex organ of the mammalian body, boasting a
diverse physiology combined with intricate cellular organization. In an effort to expand our …

Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …

We acquired a rapidly preserved human surgical sample from the temporal lobe of the
cerebral cortex. We stained a 1 mm3 volume with heavy metals, embedded it in resin, cut …

Flexible behaviors over long timescales are thought to engage recurrent neural networks in
deep brain regions, which are experimentally challenging to study. In insects, recurrent …

Cortical organoids are self-organizing three-dimensional cultures that model features of the
developing human cerebral cortex,. However, the fidelity of organoid models remains …

Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …

Progressive multiple sclerosis (MS) is characterized by unrelenting neurodegeneration,
which causes cumulative disability and is refractory to current treatments. Drug development …

Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …

Primates and rodents, which descended from a common ancestor around 90 million years
ago, exhibit profound differences in behaviour and cognitive capacity; the cellular basis for …

Human-induced pluripotent stem cells (hiPSCs) have emerged as a promising in vitro model
system for studying neurodevelopment. However, current models remain limited in their …