Classification and characterization of neuronal types are critical for understanding their
function and dysfunction. Neuronal classification schemes typically rely on measurements of …

Recent development of spatial transcriptomics (ST) is capable of associating spatial
information at different spots in the tissue section with RNA abundance of cells within each …

Glioblastoma is a devastating form of brain cancer. To identify aspects of tumor
heterogeneity that may illuminate drivers of tumor invasion, we created a glioblastoma tumor …

Adult cortical areas consist of specialized cell types and circuits that support unique higher-
order cognitive functions. How this regional diversity develops from an initially uniform …

Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased
samples of the diverse cell types in the brain,–. With the proliferation of multi-omics datasets …

INTRODUCTION The brains of extant animals have evolved over hundreds of millions of
years from simple circuits. Cell types diversified, connections elaborated, and new brain …

INTRODUCTION Human genetic studies have revealed long lists of genes and loci
associated with risk for many diseases and disorders, but to systematically evaluate their …

The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic
capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To …

Brain maps are essential for integrating information and interpreting the structure-function
relationship of circuits and behavior. We aimed to generate a systematic classification of the …

The diversity of cell types is a challenge for quantifying aging and its reversal. Here we
develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific …