Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Fluorouracil (5-FU) has been an important anti-cancer drug to date. With an increase in the
knowledge of its mechanism of action, various treatment modalities have been developed …

Pancreatic ductal adenocarcinoma (PDAC) accounts for about 3% of all cancers in the
United States and about 7% of all cancer deaths. Despite the lower prevalence relative to …

Simple Summary For the small subset of pancreatic ductal adenocarcinoma (PDAC) patients
with loss-of-function mutations to BRCA1/2 or PALB2, both first-line and maintenance …

Deficiency in DNA damage response (DDR) genes leads to impaired DNA repair functions
that will induce genomic instability and facilitate cancer development. However, alterations …

Personalized treatments and predictive biomarkers of pancreatic cancer (PDAC) are still
lacking. Recently germline mutations in BRCA 1 and 2 genes, leading to homologous repair …

This work was performed by the importance of applications of nanostructures in drug
delivery processes especially for anticancer consumption. Fluorouracil (FU) is a known …

Mutated germline alleles in the DNA damage repair (DDR) genes “breast cancer gene
1”(BRCA1) and BRCA2 have originally been identified as major susceptibility genes in …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) has a notoriously bad
prognosis due to its high mortality and lack of good therapies. Chemotherapy is the current …

Gastrointestinal (GI) malignancies are a major global health burden, with high mortality
rates. The identification of novel therapeutic strategies is crucial to improve treatment and …