Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which
is the most common form of liver disease and is present in up to∼ 70% of individuals who …

As a major component of cell membrane lipids, Arachidonic acid (AA), being a major
component of the cell membrane lipid content, is mainly metabolized by three kinds of …

A distinctive feature of stem cells is their capacity to self-renew to maintain pluripotency.
Studies of genetically-engineered mouse models and recent advances in metabolomic …

Peroxisome proliferator-activated receptor gamma (PPARγ) has been implicated in the
pathology of numerous diseases involving diabetes, stroke, cancer, or obesity. It is …

Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia
associated with the metabolic syndrome and type 2 diabetes. In spite of being effective in …

Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …

The modulation of the intestinal microbiota by high-fat diet (HFD) has a major impact on both
immunological and metabolic functions of the host. Taking this into consideration, the aim of …

Stem-cell function is an exquisitely regulated process. Thus far, the contribution of metabolic
cues to stem-cell function has not been well understood. Here we identify a previously …

The PPARs are a subfamily of three ligand-inducible transcription factors, which belong to
the superfamily of nuclear hormone receptors. In mammals, the PPAR subfamily consists of …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors of nuclear hormone receptor superfamily comprising of the following three subtypes …