Multimorbidity (two or more coexisting conditions in an individual) is a growing global
challenge with substantial effects on individuals, carers and society. Multimorbidity occurs a …

Mental health is critically important to everyone, everywhere. All over the world, mental
health needs are high but responses are insufficient and inadequate. The World mental …

Background Behavioral activation is an effective treatment for reducing depression. As
depressive disorders affect many people worldwide, internet-based behavioral activation …

Multimorbidity is a complex challenge affecting individuals, families, caregivers, and health
systems worldwide. The burden of multimorbidity is remarkable in low-and middle-income …

The association between health-related role limitations in the mental and physical
subdomains and clinical status (ie, chronic disease and comorbid depressive symptoms) is …

Background Depression and anxiety contribute to an estimated 74.6 million years of life with
disability, and 80% of this burden occurs in low-and middle-income countries (LMICs) …

Background Behavioral activation is recognized as a stand-alone, evidence-based therapy
for depression. Internet-delivered psychological interventions are easy to access and low …

Therapeutic interventions are typically evaluated in individual, parallel group trials, which
are time consuming and provide limited information on comparative efficacy. Clinical …

Artificial intelligence is disrupting the field of mental healthcare through applications in
computational psychiatry, which leverages quantitative techniques to inform our …

Scalable solutions to treat depression in older adults in low-resourced settings are urgently
needed. The PRODIGITAL-D pragmatic, single-blind, two-arm, individually randomized …