Simple Summary Beyond mutations, epigenetic changes have been described as drivers for
cancer as well. While leaving the overall DNA structure intact, they can be responsible for …

Despite enormous progress in the treatment of many malignancies, the development of
cancer resistance is still an important reason for cancer chemotherapy failure. Increasing …

The nucleus is considered the ideal target for anti‐tumor therapy because DNA and some
enzymes in the nucleus are the main causes of cell canceration and malignant proliferation …

Bromodomain and extraterminal (BET) proteins bind acetylated lysine residues in histones
and nonhistone proteins via tandem bromodomains and regulate chromatin dynamics …

Cancer is a deadly disease. There is no drug yet for the treatment of some types of cancer.
New drug trials are being conducted to treat this disease. One of them is HDAC‐based multi …

Histone deacetylases (HDACs) are a class of enzymes that remove acetyl from the ε-N-
acetyl lysine of histones, allowing histones to wrap DNA more tightly. HDACs play an …

Histone deacetylases, as a new class of anticancer targets, could maintain homeostasis by
catalyzing histone deacetylation and play important roles in regulating the expression of …

Despite the encouraging clinical progress of chemotherapeutic agents in cancer treatment,
innovation and development of new effective anticancer candidates still represents a …

NEDDylation, a post-translational modification through three-step enzymatic cascades,
plays crucial roles in the regulation of diverse biological processes. NEDD8-activating …

Histone deacetylases (HDACs) play an important role in regulating the expression of genes
involved in tumorigenesis and tumor maintenance, and hence they have been considered …