On optimal designs for clinical trials: an updated review
Optimization of clinical trial designs can help investigators achieve higher quality results for
the given resource constraints. The present paper gives an overview of optimal designs for …
the given resource constraints. The present paper gives an overview of optimal designs for …
Action video games normalise the phonemic awareness in pre-readers at risk for developmental dyslexia
Action video-games (AVGs) could improve reading efficiency, enhancing not only visual
attention but also phonological processing. Here we tested the AVG effects upon three …
attention but also phonological processing. Here we tested the AVG effects upon three …
Selecting a randomization method for a multi-center clinical trial with stochastic recruitment considerations
Background The design of a multi-center randomized controlled trial (RCT) involves multiple
considerations, such as the choice of the sample size, the number of centers and their …
considerations, such as the choice of the sample size, the number of centers and their …
Pharmacometrics meets statistics—A synergy for modern drug development
Modern drug development problems are very complex and require integration of various
scientific fields. Traditionally, statistical methods have been the primary tool for design and …
scientific fields. Traditionally, statistical methods have been the primary tool for design and …
Hypotensive effects of exercise training: are postmenopausal women with hypertension non-responders or responders?
MLV Ferreira, A Castro, SG de Oliveira Nunes… - Hypertension …, 2024 - nature.com
We tested the hypothesis that increasing the exercise dose or changing the exercise mode
would augment hypotensive effects when traditional aerobic exercise training failed to …
would augment hypotensive effects when traditional aerobic exercise training failed to …
Optimal placebo-treatment comparisons in trials with an incomplete within-subject design and heterogeneous costs and variances
M Moerbeek - Plos one, 2023 - journals.plos.org
The aim of a clinical trial is to compare placebo to one or more treatments. The within-
subject design is known to be more efficient than the between-subject design. However, in …
subject design is known to be more efficient than the between-subject design. However, in …
Optimal allocation of clusters in stepped wedge designs with a decaying correlation structure
M Moerbeek - Plos one, 2023 - journals.plos.org
The cluster randomized stepped wedge design is a multi-period uni-directional switch
design in which all clusters start in the control condition and at the beginning of each new …
design in which all clusters start in the control condition and at the beginning of each new …
Limb occlusion pressure versus standard tourniquet inflation pressure in minor hand surgery: a randomized controlled trial
T Kanchanathepsak, NC Pukrittayakamee… - Journal of Orthopaedic …, 2023 - Springer
Background In minor hand surgery, tourniquet is typically inflated to 250 mmHg. The
pressure may be too high and cause unnecessary adverse effects. Limb occlusion pressure …
pressure may be too high and cause unnecessary adverse effects. Limb occlusion pressure …
Collaborative community mental health and aged care services with peer support to prevent late-life depression: study protocol for a non-randomised controlled trial
Background Late-life depression is common, modifiable, yet under-treated. Service silos and
human resources shortage contribute to insufficient prevention and intervention. We …
human resources shortage contribute to insufficient prevention and intervention. We …
Optimal allocation to treatments in a sequential multiple assignment randomized trial
A Morciano, M Moerbeek - Statistical Methods in Medical …, 2021 - journals.sagepub.com
One of the main questions in the design of a trial is how many subjects should be assigned
to each treatment condition. Previous research has shown that equal randomization is not …
to each treatment condition. Previous research has shown that equal randomization is not …