The neuromodulator adenosine, acting through activation of four defined metabotropic
receptors called A 1, A 2A, A 2B and A 3, has been proposed as an endogenous …

High sugar consumption is a risk factor for metabolic disturbances leading to memory
impairment. Thus, rats subject to high sucrose intake (HSu) develop a metabolic syndrome …

Purinergic signaling involves the actions of purine nucleotides and nucleosides (such as
adenosine) at P1 (adenosine), P2X, and P2Y receptors. Here, we present recent data …

Microglia, which serve as the defensive interface of the nervous system, are activated in
many neurological diseases. Their role as immune responding cells has been extensively …

Seizures are due to excessive, synchronous neuronal firing in the brain and are
characteristic of epilepsy, the fourth most prevalent neurological disease. We report …

Adenosine is a neuromodulator acting through inhibitory A1 receptors (A1Rs) and facilitatory
A2ARs. Since A2AR antagonists attenuate memory deficits in aged animals and memory …

The hippocampus is comprised of two distinct subfields that show different responses to
hypoxic-ischemic brain injury: the CA1 region is particularly susceptible whereas the dentate …

The management of schizophrenia endophenotypes, namely positive, negative, and
cognitive symptoms is still an open goal, justifying the search of novel therapeutic avenues …

Adenosine is a pleiotropic bioactive with potent neuromodulatory properties. Due to its
ability to easily cross the blood–brain barrier, it can act as a signaling molecule between the …

Adenosine exerts its dual functions of homeostasis and neuromodulation in the brain by
acting at mainly 2 G-protein coupled receptors, called A1 and A2A receptors. The adenosine …