Renal oxidative vulnerability due to changes in mitochondrial-glutathione and energy homeostasis in a rat model of calcium oxalate urolithiasis

E Meimaridou, E Lobos… - American Journal of …, 2006 - journals.physiology.org
Calcium oxalate monohydrate (COM) crystals are the commonest component of kidney
stones. Oxalate and COM crystals in renal cells are thought to contribute to pathology via …

[HTML][HTML] Polymorphic variations and mRNA expression of the genes encoding interleukins as well as enzymes of oxidative and nitrative stresses as a potential risk of …

P Wigner-Jeziorska, R Grębowski, J Saluk, M Bijak… - Plos one, 2023 - journals.plos.org
Urolithiasis is one of the most common urological diseases worldwide with an unclear
aetiology. However, a growing body of evidence suggests the potential role of molecular …

The chemical disruption of human metabolism

SJ Genuis, E Kyrillos - Toxicology Mechanisms and Methods, 2017 - Taylor & Francis
Background: Recent evidence highlights the reality of unprecedented human exposure to
toxic chemical agents found throughout our environment–in our food and water supply, in …

Modulatory effect of 4-phenyl butyric acid on hyperoxaluria-induced renal injury and inflammation

M Sharma, AS Naura, SK Singla - Molecular and Cellular Biochemistry, 2019 - Springer
Hyperoxaluria-associated deposition of calcium oxalate crystals results from oxalate-
induced renal injury and inflammation. The present study was designed to evaluate the …

The preventive and therapeutic effects of α-lipoic acid on ethylene glycol-induced calcium oxalate deposition in rats

Z Wang, Y Bai, J Wang, J Wang - International urology and Nephrology, 2020 - Springer
Objective To investigate the effect of α-lipoic acid (α-LA) in the prevention and treatment of
ethylene glycol-induced calcium oxalate deposition in a rat model and preliminary …

[引用][C] 草酸, 草酸钙晶体-上皮细胞相互作用与肾结石

代海涛, 陈志强, 叶章群 - 国际泌尿系统杂志, 2006

Exposure of Madin-Darby canine kidney (MDCK) cells to oxalate and calcium oxalate crystals activates nicotinamide adenine dinucleotide phosphate (NADPH) …

A Khan, K Byer, SR Khan - Urology, 2014 - Elsevier
Objective To investigate nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase
activity in Madin-Darby canine kidney (MDCK) cells and the production of reactive oxygen …

Elevated levels of miR‐155 in blood and urine from patients with nephrolithiasis

YY Hu, WD Dong, YF Xu, XD Yao… - BioMed Research …, 2014 - Wiley Online Library
Background. Both circulating and urinary miRNAs may represent a potential noninvasive
molecular biomarker capable of predicting chronic kidney disease, and, in the present study …

miR-155 facilitates calcium oxalate crystal-induced HK-2 cell injury via targeting PI3K associated autophagy

X Chen, XB Zhang, DJ Li, GN Qi, YQ Dai, J Gu… - Experimental and …, 2020 - Elsevier
Nephrolithiasis is one of the most common and highly recurrent diseases worldwide.
Accumulating evidence revealed the elevated miR-155 levels both in serum and urine of …

Intestinal and renal handling of oxalate loads in normal individuals and stone formers

J Knight, RP Holmes, DG Assimos - Urological research, 2007 - Springer
The renal handling and intestinal absorption of dietary oxalate are believed to be risk factors
for calcium oxalate stone formation. In this study, we have examined the time and dose …