There is a need to identify high-risk features that predict early-onset atherosclerotic
cardiovascular disease (ASCVD). The authors provide insights to help clinicians identify and …

Remarkable transformations in science and healthcare have resulted in declines in mortality
from cardiovascular disease over the past several decades, largely driven by progress in …

Importance The clinical utility of polygenic risk scores (PRS) for coronary artery disease
(CAD) has not yet been established. Objective To investigate the ability of a CAD PRS to …

Background Coronary artery calcium (CAC) is a measure of atherosclerotic burden and is
well-validated for risk stratification in middle-to older-aged adults. Few studies have …

Coronary artery calcium (CAC) is a specific marker of coronary atherosclerosis that can be
used to measure calcified subclinical atherosclerotic burden. The Agatston method is the …

A steady rise in cardiovascular morbidity and mortality has been observed in young adults
within the last decades. This trend corresponds to an increasing prevalence of traditional …

Background Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death
worldwide, driven primarily by coronary artery disease (CAD). ASCVD risk estimators such …

Risk factor–based models fail to accurately estimate risk in select populations, in particular
younger individuals. A sizable number of people are also classified as being at intermediate …

Aims To evaluate the ability of Systematic COronary Risk Estimation 2 (SCORE2) and other
pre-screening methods to identify individuals with high coronary artery calcium score …

Abstract Aims American College of Cardiology/American Heart Association 2019 prevention
guidelines recommend utilizing coronary artery calcium (CAC) to stratify cardiovascular risk …