Differentiation of neurons, astrocytes, oligodendrocytes and microglia from human induced pluripotent stem cells to form neural tissue-on-chip: a neuroinflammation …
P Saglam-Metiner, E Duran, L Sabour-Takanlou… - Stem Cell Reviews and …, 2024 - Springer
Advances in stem cell (SC) technology allow the generation of cellular models that
recapitulate the histological, molecular and physiological properties of humanized in vitro …
recapitulate the histological, molecular and physiological properties of humanized in vitro …
HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) is essential to elicit type I
interferon cascade response; thus, the activity of cGAS must be strictly regulated to boost the …
interferon cascade response; thus, the activity of cGAS must be strictly regulated to boost the …
Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage
H Homma, Y Yoshioka, K Fujita, S Shirai… - Communications …, 2024 - nature.com
Better understanding of the earliest molecular pathologies of all neurodegenerative
diseases is expected to improve human therapeutics. We investigated the earliest molecular …
diseases is expected to improve human therapeutics. We investigated the earliest molecular …
[HTML][HTML] The neuroprotective effects of caffeic acid phenethyl ester against methamphetamine-induced neurotoxicity
B Yang, X Tan, Y Chen, J Lin, J Liang, X Yue… - Ecotoxicology and …, 2024 - Elsevier
Methamphetamine (METH) is a highly abused substance on a global scale and has the
capacity to elicit toxicity within the central nervous system. The neurotoxicity induced by …
capacity to elicit toxicity within the central nervous system. The neurotoxicity induced by …
IL-11 Plays a Protective Anti-Inflammatory Role in Spinal Cord Injury by Inhibiting Microglial Activation Through Suppression of ISG15 Signaling
Y Sun, Z Geng, S Xue, L Xiao, Y Xu, Z Wang, X Liu, J Li… - 2023 - papers.ssrn.com
Objective: An overactive inflammatory response accompanied by elevated levels of
inflammatory mediators is a key factor contributing to secondary damage after spinal cord …
inflammatory mediators is a key factor contributing to secondary damage after spinal cord …