Selected vulnerability of neurons in Huntington's disease suggests that alterations occur in a
cellular process that is particularly critical for neuronal function. Supporting this idea …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. In 1993
the mutation that causes HD was identified as an unstable expansion of CAG repeats in the …

Polyglutamine expansion causes Huntington disease (HD) and at least seven other
neurodegenerative diseases. In HD, N-terminal fragments of huntingtin with an expanded …

Huntington's disease (HD) is an autosomal–dominant neurodegenerative disorder caused
by a CAG trinucleotide repeat expansion in the HD gene. The expanded repeats are …

Huntington's disease (HD) is a devastating neurodegenerative disorder that directly affects
more than 1 in 10,000 persons in Western societies but, as a family disorder with a long …

Mouse models for Huntington's Disease (HD) and HD patients demonstrate motor and
behavioral dysfunctions, such as progressive loss of coordination and memory, and share …

Advances in human genetics are leading to the discovery of new disease-causing mutations
at a remarkable rate. Many such mutations, however, occur in genes that encode for proteins …

Huntington's disease (HD) is a prototypical neurodegenerative disease in which there is
selective neuronal degeneration, which leads to progressive disability, manifesting itself as …

Modifying the length of the Huntington's disease (HD) CAG repeat, the major determinant of
age of disease onset, is an attractive therapeutic approach. To explore this we are …

Huntington's disease (HD) is an inherited neurodegenerative disorder. The mutation which
causes the disease is an expansion in the number of repetitions of three nucleotides, C, A …