Morphometric studies of the tail of the caudate nucleus, the site where the pathology is first
seen, were performed on 16 brain specimens collected from individuals at risk for inheriting …

A mechanistic link between cellular energetic defects and the pathogenesis of Huntington's
disease (HD) has long been hypothesized based on the cardinal observations of …

Huntington disease (HD) is an adult onset neurodegenerative disorder that predominantly
affects the striatum and cortex despite ubiquitous expression of mutant huntingtin (htt). Here …

While the role of the mutated Huntington's disease (HD) protein in the pathogenesis of HD
has been the focus of intensive investigation, the normal protein has received less attention …

Huntington's disease (HD) is a progressive neurodegenerative disease characterized by
preferential loss of neurons in the striatum in patients, which leads to motor and cognitive …

The first 17 amino acids of Huntington's disease (HD) protein, huntingtin, comprise an
amphipathic alpha-helical domain that can target huntingtin to the endoplasmic reticulum …

Huntington's disease (HD) is an autosomal dominant, progressive, and fatal
neurodegenerative disorder caused by an expanded polyglutamine cytosine–adenine …

Major insights have been attained into the molecular pathology of the trinucleotide repeat
neurodegenerative diseases over the past decade. Genetic definition has allowed …

Synaptic dysfunction and altered calcium homeostasis in the brain is common to many
neurodegenerative disorders. Among these, Huntington disease (HD), which is inherited in …

Huntington disease (HD) is an adult-onset neurodegenerative disease caused by a toxic
gain of function in the huntingtin (htt) protein. The contribution of wild-type htt function to the …