Synaptic dysfunction and altered calcium homeostasis in the brain is common to many
neurodegenerative disorders. Among these, Huntington disease (HD), which is inherited in …

Asymptomatic Huntington's disease (HD) patients exhibit memory and cognition deficits that
generally worsen with age. Similarly, long-term potentiation (LTP), a form of synaptic …

It is now more than 7 years since the genetic mutation causing Huntington's disease (HD)
was first identified. Unstable CAG expansion in the IT15 gene, responsible for disease, is …

Corticostriatal atrophy is a cardinal manifestation of Huntington's disease (HD). However,
the mechanism (s) by which mutant huntingtin (mHTT) protein contributes to the …

Huntington's disease is an autosomal dominant neurodegenerative disorder that is
characterized by motor, cognitive, and psychiatric alterations. The mutation responsible for …

Ubiquitination of misfolded proteins, a common feature of many neurodegenerative
diseases, is mediated by different lysine (K) residues in ubiquitin and alters the levels of …

The identification of the Huntington's disease (HD) mutation as a CAG/polyglutamine repeat
expansion enabled the generation of transgenic rodent models and gene-targeted mouse …

The neurodegenerative disease Huntington's disease (HD) is caused by an expanded
polyglutamine (polyQ) tract in the protein huntingtin (htt). Although the gene encoding htt …

Over the past decades, Caenorhabditis elegans (C. elegans) has been widely used as a
model system because of its small size, transparent body, short generation time and lifespan …

The identification of the mutation causing Huntington's disease (HD) has led to the
generation of a large number of mouse models. These models are used to further enhance …